Rabbitpolyclonalantibody
PooledSerumTheantigenisapeptidecorrespondingtoaminoacidresiduesfromtheC-terminusofratERK/MAPK.
Theantibodyispreparedfrompooledrabbitserumbyaffinitypurification.
Extracellular-SignalRegulatedKinase/Mitogen-ActivatedProteinKinase(ERK/MAPK)isanintegralcomponentofcellularsignalingduringmitogenesisanddifferentiationofmitoticcellsandalsoisthoughttoplayakeyroleinlearningandmemory(AdamsandSweatt,2002;Ahn,1993;TanoueandNishida,2003;JohnsonandLapadat,2002).TheactivityofthiskinaseisregulatedbydualphosphorylationatThr202andTyr204(Ahn,1993).
100µlin10mMHEPES(pH7.5),150mMNaCl,100µgBSApermland50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.
Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.
Erickson,C.A.,Ray,B.,Wink,L.K.,Bayon,B.L.,Pedapati,E.V.,Shaffer,R.,Schaefer,T.L.andLahiri,D.K.,2016.Initialanalysisofperipherallymphocyticextracellularsignalrelatedkinaseactivationinautism.JournalofPsychiatricResearch.PMID:27743527
PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。