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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/p38 MAPK (Thr180, Tyr182) Antibody/p190-1802/100 µl
产品编号:p190-1802
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/p38 MAPK (Thr180, Tyr182) Antibody/p190-1802/100 µl
商品介绍

Rabbitpolyclonalantibody

PooledSerum
Size:
100µl
Formulation:
AffinityPurifiedfromPooledSerum
Specificity:
Rat,Mouse,Human,Bovine,Chicken,Non-humanprimate,Zebrafish,Canine
Applications:
WB1:1,000IHC1:250
Species:
Rabbit
GeneName:
MAPK14
MolecularReference:
~39kDa
CiteThisAntibody:
PhosphoSolutionsCat#p190-1802,RRID:AB_2492195
Antigen/Purification:ExpandCollapse

Theantigenisaphosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Thr180andphospho-Tyr182ofratp38MAPK.

Theantibodyis preparedfrompooledrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.

BIOLOGicalSignificance:ExpandCollapse

ThethreeMitogen-ActivatedProteinKinases(MAPKs)areevolutionarilyconservedproteinkinasesthatcontrolavastarrayofcellularprocesses.p38MAPKisoneofthesekinasesanditisactivatedbybothinflammatorycytokinesandbystress(JohnsonandLapadat,2002;ShiandGaestel,2002).Thep38MAPKisthoughttobeparticularlyimportantindiseaseslikeasthmaandautoimmunitybutitalsoplaysimportantrolesinthestressresponseofthenervoussystem(PhilipandArmstead,2003;Yingetal.,2002).LiketheotherMAPKs,p38isactivatedbyadualspecificitykinasethatphosphorylatesThr180andTyr182(Linetal.,1995).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

ProductSpecificReferences

Perrott,K.M.,Wiley,C.D.,Desprez,P.Y.andCampisi,J.,2017.Apigeninsuppressesthesenescence-associatedsecretoryphenotypeandparacrineeffectsonbreastcancercells.GeroScience,pp.1-13.PMID:28378188

Xu,P.,Zhou,Z.,Xiong,M.,Zou,W.,Deng,X.,Ganaie,S.S.,Kleiboeker,S.,Peng,J.,Liu,K.,Wang,S.andYe,S.Q.,2017.ParvovirusB19NS1proteininducescellcyclearrestatG2-phasebyactivatingtheATR-CDC25C-CDK1pathway.PLoSpathogens,13(3),p.e1006266.PMID:28264028

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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