PhosphoSolutions/Ribosomal Protein S6 (Ser244) Antibody/p1860-244/100 µl,PhosphoSolutions,,PhosphoSolutions,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：PhosphoSolutions/Ribosomal Protein S6 (Ser244) Antibody/p1860-244/100 µl

产品编号：p1860-244

市场价：¥4574.70

场地：美国(厂家直采)

产品分类：抗体类>一抗>功能性抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$345.00

品牌： PhosphoSolutions

公司：PhosphoSolutions

公司分类：

商品介绍

Rabbitpolyclonalantibody

PooledSerum

Size:: 100µl
Formulation:: AffinityPurifiedfromPooledSerum
Specificity:: Rat,Mouse,Human,Xenopus,Chicken,Non-humanprimate,Zebrafish,GuineaPig
Applications:: WB1:1000
Species:: Rabbit
MolecularReference:: ~28kDa
CiteThisAntibody:: PhosphoSolutionsCat#p1860-244,RRID:AB_2492234

Antigen/Purification:ExpandCollapse

Theantigenis aphosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Ser²⁴⁴ofmouserpS6.

Theantibodyispreparedfrompooledrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.

BIOLOGicalSignificance:ExpandCollapse

RibosomalproteinS6(rpS6)isacriticalcomponentofthe40Sribosomalsubunitthatmediatestranslationinitiationatthe5′-m7GpppGcapofmRNA.TherpS6proteinisbothcytoplasmicandnuclearlocalized(ChenandDittmer2011).Inresponsetomitogenicstimuli,rpS6undergoesorderedC-terminalphosphorylationbyp70S6kinasesandp90ribosomalS6kinasesonfourSerresidues(Ser²³⁵,Ser²³⁶,Ser²⁴⁰,andSer²⁴⁴)whosemodificationpotentiatesrpS6capbindingactivity(Hutchinsonetal.,2011).Additionally,rpS6phosphorylationandfunctionarehighlyregulatedandhavebeenimplicatedintheregulationoftranslationalinitiationandproteinsynthesisinresponsetoextracellularstimulisuchasTRAILandgammainterferon(IFN-γ),aswellasuponactivationofthephosphatidylinositol3-kinase(PI3K)–Akt–mTORpathway(ChenandDittmer2011).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgBSApermland50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

ChenWandDittmerD(2011)RibosomalproteinS6(RPS6)interactswiththelatency-associatednuclearantigen(LANA)ofKaposisarcomaassociatedherpesvirus(KSHV).J.Virol.189495-9505

FumagalliS.andThomas,G.(2000).S6phosphorylationandsignaltransduction.InTranslationalcontrolofgeneexpression(eds.N.Sonenbergetal.),pp.695-717.Cold

SpringHarborLaboratoryPress,ColdSpringHarbor,NY.HutchinsonJA,ShanwareNP,ChangH,TibbettsRS.(2011)RegulationofribosomalproteinS6phosphorylationbycaseinkinase1andproteinphosphatase1.JBiolChem10:8688-96

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik，他们在 Paul Greengard 博士的实验室共同工作，Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区，是一支敬业、友好、勤奋的科学家团队，致力于为您提供最优质的抗体和业内客户支持。

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