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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Thyroid Hormone Receptor Antibody, α2-Isotype/1230-TRa2/100 µl
产品编号:1230-TRa2
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Thyroid Hormone Receptor Antibody, α2-Isotype/1230-TRa2/100 µl
商品介绍

Mousemonoclonalantibody

Size:
100µl
Formulation:
ProteinGPurified
Specificity:
Rat,Mouse,Human,Bovine,Non-humanprimate
Applications:
WB1:1,000
Species:
Mouse
MolecularReference:
~58kDa
CiteThisAntibody:
PhosphoSolutionsCat#1230-TRa2,RRID:AB_2492262
Antigen/Purification:ExpandCollapse

Theantigenisa PeptidecorrespondingtoaminoacidresiduesfromtheN-terminalregionofhumanthyroidhormonereceptor,α2-isotype.

TheantibodyispreparedfrommouseascitesbyammoniumsulfateprecipitationfollowedbyaffinitypurificationonaProteinGcolumn.

BIOLOGicalSignificance:ExpandCollapse

Thyroidhormonesareessentialfordevelopmentofthecentralnervoussystemanddeficitsinthesehormonesduringdevelopmentaffectssuchcognitivefunctionsaslearningandmemory(Ambroginietal.,2005;ChanandKilby,2000).Thyroidhormonesexerttheirphysiologicalrolemainlythroughbindingtospecificnuclearreceptorsincludingthepredominantisoformsofthyroidhormonereceptors,TRα1,TRα2,TRβ1andTRβ2.TRα1,TRβ1andTRβ2bindT3withhighaffinityandalsobindtothyroidhormoneresponseelements(TREs)onchromatintoregulatethetranscriptionalprocessesinseveraltargettissues,includingadultratbrain(Constantinouetal.,2005).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

AmbroginiP,CuppiniR,FerriP,ManciniC,CiaroniS,VociA,GerdoniE,GalloG(2005)Thyroidhormonesaffectneurogenesisinthedentategyrusofadultrat.Neuroendocrinology81:244-253.

ChanS,KilbyMD(2000)Thyroidhormoneandcentralnervoussystemdevelopment.JEndocrinol165:1-8.

ConstantinouC,MargarityM,ValcanaT(2005)Region-specificeffectsofhypothyroidismontherelativeexpressionofthyroidhormonereceptorsinadultratbrain.MolCellBiochem278:93-100.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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