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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Tubulin Antibody, Beta III/2020-TUB/100 µl
产品编号:2020-TUB
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Tubulin Antibody, Beta III/2020-TUB/100 µl
商品介绍

Mousemonoclonalantibody

Size:
100µl
Formulation:
ProteinGPurified
Specificity:
Mostmammals
Applications:
WB1:10,000IHC1:1,000
Species:
Mouse
MolecularReference:
~55kDa
CiteThisAntibody:
PhosphoSolutionsCat#2020-TUB,RRID:AB_2492275
Antigen/Purification:ExpandCollapse

TheantigenisasyntheticpeptidecorrespondingtobetaIIItubulin.

TheantibodyisProteinGpurifiedculturesupernatant.

BIOLOGicalSignificance:ExpandCollapse

Tubulinisthemajorconstituentofmicrotubules,existingasaheterodimeroftheαandβsubunits.ThebetaIIIisoformoftubulinisfoundalmostexclusivelyinneuronalprocessesofadulttissuesandisthereforeanexcellentMarkerforneurons.Neuronspecific,posttranslationalmodificationswithintheC-terminaldomainofbetaIIItubulinhavebeenshowntobedevelopmentallyregulatedsuggestingthattheymayservetomodulatetheinteractionoftubulinwithmicrotubuleassociatedproteins(Leeetal.,1990).Additionally,betaIIItubulinhasbeenfoundtobehighlyexpressedincancercellssuchassmallcelllungcancer,largecellneuroendocrinecarcinomaandadenocarcinomasandiscorrelatedwithanincreasinghistologicaldegreeofmalignancy(Katsetosetal.,2003)

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.

ProductSpecificReferences

Ka,M.,&Kim,W.Y.(2015).Microtubule-ActinCrosslinkingFactor1IsRequiredforDendriticArborizationandAxonOutgrowthintheDevelopingBrain.Molecularneurobiology,November,1-15.PMID:26526844.

Cooper,R.J.,&Spitzer,N.(2015).SilvernanoparticlesatsublethalconcentrationsdisruptCytoskeletonandneuritedynamicsinculturedadultneuralstemcells.Neurotoxicology,48,231-238.PMID:25952507.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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