Sheeppolyclonalantibody
Theantigenisa purifiedguineapigcalretinin.
TheantibodyisproteinApurifiedsheepserum.
Calretininisacalcium-bindingproteininvolvedincalciumsignaling.Itisabundantlyexpressedthroughoutthecentralnervoussystem,retinaandmanyothertissues.Studieshaveshownthatcalretininmayplayaroleinneuroprotectionbybufferingintracellularcalcium(LukasandJones1994,Weisenhornetal.,1996).Additionally,calretininselectivelystainsmesothelialcellsthusmakingitanimportantMarkerfordifferentiatingmalignantmesotheliomafromcarcinomas(Attanoosetal.,2000).
100µlin10mMTris,100mMNaCl.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.
AttanoosRL,DojcinovSD,WebbR,GibbsAR.(2000)Anti-mesothelialmarkersinsarcomatoidmesotheliomaandotherspindlecellneoplasms.Histopathology.37(3):224-31.
IsaacsKR,WinskyL,StraussKI,JacobowitzDM.(1995)Quadruplecolocalizationofcalretinin,calcitoningene-relatedpeptide,vasoactiveintestinalpeptide,andsubstancePinfiberswithinthevillioftheratintestine.CellTissueRes.,280(3):639-51.
LukasW,JonesKA(1994)Corticalneuronscontainingcalretininareselectivelyresistanttocalciumoverloadandexcitotoxicityinvitro.Neurosci.61(2):307-16.
WeisenhornDMV,Weruaga-PrietoE,CelioMR(1996)Calretininimmunoreactivityinorganotypicculturesoftheratcerebralcortex:effectsofserumdeprivation.Exp.BrainRes.108(1):101-112.
PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。