Rabbitpolyclonalantibody
Theantigenisa nativecholineacetyltransferasepurifiedfromhumanplacenta.
Theantibodyisneatserum.
CholineacetyltransferaseisaneuronalenzymewhichcatalyzesthereactionbetweenAcetylCoAandcholineresultingintheformationofacetylcholine.ItisthereforefoundprimarilyincholinergicneuronsmakingitavaluableMarkerfordiseasesassociatedwithdecreasedcholinergicfunctionsuchasSchizophrenia,Alzheimer’sdisease(AD)andDownsyndrome(Holtetal.1999).DecreasedcholineacetyltransferaseactivityinparticularhasbeenshowninSchizophrenicsubjects(Karsonetal1993).IthasfurThermorebeendemonstratedthatinpatientswithAD,therearesignificantlylowerlevelsofcorticalChATthatcorrelatewithseverityofthediseaseasmeasuredbylossofneuropsychologicalfunction(Baskinetal.1999).
100µlneatserum..Adequateamountofmaterialtoconduct10-miniWesternBlots.
Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.
KarsonCN,CasanovaMF,KleinmanJE,GriffinWS(1993)Cholineacetyltransferaseinschizophrenia.Am.J.Psychiatry150:454-459.
HoltDJ,HermanMM,HydeTM,KleinmanJE,CintonCM,GermanDC,HershLB,GreybielAM,SaperCB(1999)Evidenceforadeficitincholinergicinterneuronsinthestriatuminschizophrenia.Neuroscience94(1):21-31.
BaskinDS,BrowningJL,PirozzoloFJ,KorporaalS,BaskinJA,AppelSH(1999)BraincholineacetyltransferaseandmentalfunctioninAlzheimerdisease.ArchNeurol.56:1121-1123.
PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。