PhosphoSolutions/Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) Antibody/p1550-503/100 µl,PhosphoSolutions,,PhosphoSolutions,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：PhosphoSolutions/Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) Antibody/p1550-503/100 µl

产品编号：p1550-503

市场价：¥4574.70

场地：美国(厂家直采)

产品分类：抗体类>一抗>功能性抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$345.00

品牌： PhosphoSolutions

公司：PhosphoSolutions

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商品介绍

Rabbitpolyclonalantibody

PooledSerum

Size:: 100µl
Formulation:: AffinityPurifiedfromPooledSerum
Specificity:: Rat,Mouse
Applications:: WB1:1,000IHC1:1,000
Species:: Rabbit
MolecularReference:: ~100kDa
CiteThisAntibody:: PhosphoSolutionsCat#p1550-503,RRID:AB_2492212

Antigen/Purification:ExpandCollapse

Theantigenisaphosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Ser⁵⁰³ofthevoltage-gatedpotassiumchannelKv3.1,conjugatedtokeyholelimpethemocyanin(KLH).

Theantibodyispreparedfrompooledrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.

BIOLOGicalSignificance:ExpandCollapse

Voltage-gatedK+channelsareimportantdeterminantsofneuronalmembraneexcitABIlity.Moreover,differencesinK+channelexpressionpatternsanddensitiescontributetothevariationsinactionpotentialwaveformsandrepetitivefiringpatternsevidentindifferentneuronalcelltypes(Maletic-Savaticetal.,1995;Pongs,1999;BlaineandRibera,1998;BurgerandRibera,1996).TheKv3.1potassiumchannelisexpressedathighlevelsinneuronsthatcharacteristicallyfirerapidtrainsofactionpotentials(Ganetal.,1999).Particularlyhighlevelsofthischannelarefoundinneuronsoftheauditorybrainstem.Theseneuronsappeartoparticipateinneuralcircuitsthatdeterminetheintensityandtimingofauditorystimuliandusethisinformationtodeterminethelocationofsoundsinspace(vonHehnetal.,2004).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

Product SpecificReferences

PingSongandLeonardK.Kaczmarek(2006)ModulationofKv3.1bPotassiumChannelPhosphorylationinAuditoryNeuronsbyConventionalandNovelProteinKinaseCIsozymesJ.Biol.Chem.,Jun2006;281:15582-15591.PMID:16595659

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik，他们在 Paul Greengard 博士的实验室共同工作，Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区，是一支敬业、友好、勤奋的科学家团队，致力于为您提供最优质的抗体和业内客户支持。

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