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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Dynamin (Ser774) Antibody/p1050-774/100 µl
产品编号:p1050-774
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Dynamin (Ser774) Antibody/p1050-774/100 µl
商品介绍

Sheeppolyclonalantibody

PooledSerum
Size:
100µl
Formulation:
AffinityPurifiedfromPooledSerum
Specificity:
Rat,Mouse,Human,Bovine,Chicken,Non-humanprimate,Canine
Applications:
WB1:1,000IF1:1,000IHC1:1,000
Species:
Sheep
MolecularReference:
~95kDa
CiteThisAntibody:
PhosphoSolutionsCat#p1050-774,RRID:AB_2492082
Antigen/Purification:ExpandCollapse

Theantigenisaphosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Ser774ofratdynamin.

Theantibodyispreparedfrompooledsheepserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.

BIOLOGicalSignificance:ExpandCollapse

Dynaminisamemberofagroupofnerveterminalproteinscalleddephosphinsthatregulatesynapticvesicleendocytosis(Cousinetal.,2001;Grahametal.,2002;Tsuboietal.,2002).Cyclindependentproteinkinase5phosphorylatesdynaminatSer774andSer778 thatarethephosphorylationsitesondynaminphosphorylatedinvivo(Tanetal.,2003).PhosphorylationofSer774byGSK3hasrecentlybeenshowntocontrolactivity-dependentbulkendocytosisofsynapticvesicles(Claytonetal.,2010).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgBSApermland50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

ProductSpecificReferences

Vargas,K.J.,Schrod,N.,Davis,T.,Fernandez-BusnADIego,R.,Taguchi,Y.V.,Laugks,U.,Lucic,V.andChandra,S.S.,2017.SynucleinsHaveMultipleEffectsonPresynapticArchitecture.CellReports,18(1),pp.161-173. PMID:28052246

SergioLeal-Ortiz,ClarissaL.Waites,RyanTerry-Lorenzo,PedroZamorano,EckartD.Gundelfinger,andCraigC.Garner(2008)PiccolomodulationofSynapsin1adynamicsregulatessynapticvesicleexocytosis.J.CellBiol.,181:831–846.PMID:18519737

TanTC,ValovaVA,MalladiCS,GrahamME,BervenLA,JuppOJ,HansraG,McClureSJ,SarcevicB,BoadleRA,LarsenMR,CousinMA,RobinsonPJ(2003)cdk5isessentialforsynapticvesicleendocytosis.NatCellBiol5:701-710. PMID:12855954

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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