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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Rabphilin 3A (Ser234) Antibody/p1553-234/100 µl
产品编号:p1553-234
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Rabphilin 3A (Ser234) Antibody/p1553-234/100 µl
商品介绍

Rabbitpolyclonalantibody

PooledSerum
Size:
100µl
Formulation:
AffinityPurifiedfromPooledSerum
Specificity:
Rat,Mouse
Applications:
WB1:1000IHC1:400
Species:
Rabbit
MolecularReference:
~82kDa
CiteThisAntibody:
PhosphoSolutionsCat#p1553-234,RRID:AB_2492222
Antigen/Purification:ExpandCollapse

Theantigenisaphosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Ser234ofrabphilin3A.

Theantibodyispreparedfrompooledrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.

BIOLOGicalSignificance:ExpandCollapse

Rabphilin-3AisaperipheralmembraneproteinthatbindsCa2+andphospholipidsandisattachedtosynapticvesiclemembranes(Geppertetal.,1994;Lietal.,1994).Theexpressionofrabphilin3AisreducedinananimalmodelofHuntington’sdisease(Smithetal.,2005).RabphilincanbephosphorylatedatSer234bybothCAMkinaseIIandPKAandthisphosphorylationhasbeensuggestedtoregulateneuronalactivityduringdevelopmentinasynapse-specificmanner(Fykseetal.,1995;FolettiandScheller,2001).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgBSApermland50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

ProductSpecificReferences

Stanic,J.,Mellone,M.,Napolitano,F.,Racca,C.,Zianni,E.,Minocci,D.,Ghiglieri,V.,Thiolat,M.L.,Li,Q.,Longhi,A.andDeRosa,A.,2017.Rabphilin3A:Anoveltargetforthetreatmentoflevodopa-induceddyskinesias.NeurobiologyofDisease.PMID:28823933

Leal-Ortiz,S.,Waites,C.L.,Terry-Lorenzo,R.,Zamorano,P.,Gundelfinger,E.D.andGarner,C.C.,2008.PiccolomodulationofSynapsin1adynamicsregulatessynapticvesicleexocytosis.TheJournalofcellbiology,181(5),pp.831-846. PMID:18519737

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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