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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Rabphilin 3A Antibody/1825-RBP/100 µl
产品编号:1825-RBP
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Rabphilin 3A Antibody/1825-RBP/100 µl
商品介绍

Rabbitpolyclonalantibody

PooledSerum
Size:
100µl
Formulation:
AffinityPurifiedfromPooledSerum
Specificity:
Rat,Mouse,Human,Bovine,Non-humanprimate,Canine
Applications:
WB1:1000
Species:
Rabbit
MolecularReference:
~82kDa
CiteThisAntibody:
PhosphoSolutionsCat#1825-RBP,RRID:AB_2492221
Antigen/Purification:ExpandCollapse

TheantigenisasyntheticpeptidecorrespondingtoaminoacidresiduesfromtheC-terminalregionofrabphilin3A.

Theantibodyis  preparedfrompooledrabbitserumbyaffinitypurificationonacolumntowhichtheC-terminalpeptideimmunogenwascoupled.

BIOLOGicalSignificance:ExpandCollapse

Rabphilin-3AisaperipheralmembraneproteinthatbindsCa2+andphospholipidsandisattachedtosynapticvesiclemembranes(Geppertetal.,1994;Lietal.,1994).Theexpressionofrabphilin3AisreducedinananimalmodelofHuntington’sdisease(Smithetal.,2005).RabphilincanbephosphorylatedatSer234bybothCAMkinaseIIandPKAandthisphosphorylationhasbeensuggestedtoregulateneuronalactivityduringdevelopmentinasynapse-specificmanner(Fykseetal.,1995;FolettiandScheller,2001).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgBSApermland50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

FolettiDL,SchellerRH(2001)Developmentalregulationandspecificbraindistributionofphosphorabphilin.JNeurosci21:5461-5472.

FykseEM,LiC,SudhofTC(1995)Phosphorylationofrabphilin-3AbyCa2+/calmodulin-andcAMPdependentproteinkinasesinvitro.JNeurosci15:2385-2395.

GeppertM,BolshakovVY,SiegelbaumSA,TakeiK,DeCamilliP,HammerRE,SüdhofTC(1994)TheroleofRab3Ainneurotransmitterrelease.Nature(Lond)369:493-497.

LiC,TakeiK,GeppertM,DaniellL,SteniusK,ChapmanER,JahnR,DeCamilliP,SüdhofTC(1994)Synaptictargetingofrabphilin-3A,asynapticvesicleCa2+/phospholipid-bindingprotein,dependsonrab3A/3C.Neuron13:885-898.

SmithR,PetersenA,BatesGP,BrundinP,LiJY(2005)Depletionofrabphilin3Ainatransgenicmousemodel(R6/1)ofHuntington’sdisease,apossIBLeculpritinsynapticdysfunction.NeurobiolDis20:673-684.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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