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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/SNAP25 Antibody/1905-SNAP/100 µl
产品编号:1905-SNAP
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/SNAP25 Antibody/1905-SNAP/100 µl
商品介绍

Rabbitpolyclonalantibody

PooledSerum
Size:
100µl
Formulation:
AffinityPurifiedfromPooledSerum
Specificity:
Rat,Mouse,Human,Bovine,Chicken,Non-humanprimate,Zebrafish,Canine,GuineaPig
Applications:
WB1:1000
Species:
Rabbit
MolecularReference:
~25kDa
CiteThisAntibody:
PhosphoSolutionsCat#1905-SNAP,RRID:AB_2492238
Antigen/Purification:ExpandCollapse

TheantigenisapeptidecorrespondingtoaminoacidresiduesfromtheC-terminalregionofratSNAP25conjugatedtokeyholelimpethemocyanin(KLH).

TheantibodyispreparedfrompooledrabbitserumbyaffinitypurificationviachromatographyonanaffinitycolumnmadewiththeC-terminalpeptideusedasantigen.

BIOLOGicalSignificance:ExpandCollapse

SNAP25(Synaptosomalassociatedproteinof25kDa)isapresynapticplasmamembraneproteinthatiswidelydistributedthroughoutthebrainandinvolvedintheregulationofneurotransmitterrelease.DecreasedlevelsofSNAP25havebeenfoundinthebrainsofpatientswithDownSyndromeandAlzheimer’sDisease(Greberetal.,1999).Inaddition,asignificantreductioninthehippocampalexpressionofSNAP25hasalsobeenfoundinpatientswithSchizophrenia(Fatemietal.,2001).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

FatemiSH,SidwellR,KistD,AkhterP,MeltzerHY,BaileyK,ThurasP,SedgwickJ(1998)Differentialexpressionofsynaptosome-associatedprotein25kDa(Snap25)inhippocampiofneonatalmicefollowingexposuretohumaninfluenzavirusinutero.BrainRes800(1):1-9.

GreberS,CairnsN,LubecG,FountoulakisM(1999)Decreasedlevelsofthesynaptosomalassociatedprotein25inthebrainsofpatientswithDownSyndromeandAlzheimer’sDisease.Electrophoresis20(4-5):928-34.

AndoK,KudoY,TakahashiM(2005)Negativeregulationofneurotransmitterreleasebycalpain:apossIBLespecificinvolvementofSnap25cleavage.JNeuRochem94(3):651-8.

FatemiSH,EarleJA,StaryJM,LeeS,SedgwickJ(2001)AlteredlevelsofthesynaptosomalassociatedproteinSnap25inhippocampusofpatientswithmooddisordersandSchizophrenia.Neuroreport.12(15):3257-62.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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