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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Synapsin I (Ser62,67) Antibody/p1560-6267/100 µl
产品编号:p1560-6267
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Synapsin I (Ser62,67) Antibody/p1560-6267/100 µl
商品介绍

Rabbitpolyclonalantibody

PooledSerum
Size:
100µl
Formulation:
AffinityPurifiedfromPooledSerum
Specificity:
Rat,Mouse,Bovine
Applications:
WB1:1000
Species:
Rabbit
GeneName:
SYN1
MolecularReference:
~78kDa
CiteThisAntibody:
PhosphoSolutionsCat#p1560-6267,RRID:AB_2492245
Antigen/Purification:ExpandCollapse

Theantigenisaphosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Ser62,67ofsynapsinI.

Theantibodyis  preparedfrompooledrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.

BIOLOGicalSignificance:ExpandCollapse

SynapsinIplaysakeyroleinsynapticplasticityinbrain(Fengetal.,2002;Nayaketal.,1996).ThiseffectisdueinlargeparttotheABIlityofthesynapsinstoregulatetheavailabilityofsynapticvesiclesforrelease.Theroleofsynapsininsynapticplasticityandinsynaptogenesisisregulatedbyphosphorylation(Jovanovicetal.,2001;Kaoetal.,2002).Ser549alongwithSer62andSer67arethesitesofSynapsinIthatarephosphorylatedbyMAPkinase(Czerniketal.,1987;Jovanovicetal.,1996).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

ProductSpecificReferences

Vargas,K.J.,Schrod,N.,Davis,T.,Fernandez-BusnADIego,R.,Taguchi,Y.V.,Laugks,U.,Lucic,V.andChandra,S.S.,2017.SynucleinsHaveMultipleEffectsonPresynapticArchitecture.CellReports,18(1),pp.161-173. PMID:28052246

Chanaday,N.L.,Vilcaes,A.A.,dePaul,A.L.,Torres,A.I.,Degano,A.L.,&Roth,G.A.(2015).GlutamateReleaseMachineryIsAlteredintheFrontalCortexofRatswithExperimentalAutoimmuneEncephalomyelitis.Molecularneurobiology,51(3),1353-1367.PMID:25037702

MelanieK.Tallent,NealVarghis,YuliyaSkorobogatko,LisaHernandez-Cuebas,KellyWhelan,DavidJ.Vocadlo,andKeithVosseller(2009)InVivoModulationofO-GlcNAcLevelsRegulatesHippocampalSynapticPlasticitythroughInterplaywithPhosphorylation.J.Biol.Chem.,Jan2009;284:174–181.PMID:19004831

SergioLeal-Ortiz,ClarissaL.Waites,RyanTerry-Lorenzo,PedroZamorano,EckartD.Gundelfinger,andCraigC.Garner(2008)PiccolomodulationofSynapsin1adynamicsregulatessynapticvesicleexocytosis.J.CellBiol.,181:831–846.PMID:18519737

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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