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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Synapsin I Antibody, 50 µl/1927-SYNP/50 µl
产品编号:1927-SYNP
市  场 价:¥3911.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$295.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Synapsin I Antibody, 50 µl/1927-SYNP/50 µl
商品介绍

Rabbitpolyclonalantibody,neatserum

Size:
50µl
Formulation:
Neatserum
Specificity:
Rat,Mouse,Human
Applications:
WB1:1000
Species:
Rabbit
MolecularReference:
~78kDa
CiteThisAntibody:
PhosphoSolutionsCat#1927-SYNP,RRID:AB_2492243
Antigen/Purification:ExpandCollapse

Theantigenisanativeproteinpurifiedfrombovinebrain.

Theantibodyisunpurifiedneatserum.

BIOLOGicalSignificance:ExpandCollapse

SynapsinIplaysakeyroleinsynapticplasticityinthebrain(Fengetal.,2002;Nayaketal.,1996).ThiseffectisdueinlargeparttotheABIlityofthesynapsinstoregulatetheavailabilityofsynapticvesiclesforrelease.Inadditiontoitsroleinplasticity,theexpressionofsynapsinIisapreciseindicatorofsynapseformation(MooreandBernstein,1989;Stoneetal.,1994).Thus,SynapsinIimmunocytochemistryprovidesavaluabletoolforthestudyofsynaptogenesis.Theroleofsynapsininsynapticplasticityandinsynaptogenesisisregulatedbyphosphorylation(Jovanovicetal.,2001;Kaoetal.,2002).

Storage

50μlneatserum.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

FengJ,ChiP,BlanpiedTA,XuYM,MagarinosAM,FerreiraA,TakahashiRH,KaoHT,McEwenBS,RyanTA,AugustineGJ,GreengardP(2002)RegulationofneurotransmitterreleasebysynapsinIII.JNeurosci22:4372-4380.

JovanovicJN,SihraTS,NairnAC,HemmingsHC,Jr.,GreengardP,CzernikAJ(2001)OpposingchangesinphosphorylationofspecificsitesinsynapsinIduringCa2+-dependentglutamatereleaseinisolatednerveterminals.JNeurosci21:7944-7953.

KaoHT,SongHJ,PortonB,MingGL,HohJ,AbrahamM,CzernikAJ,PieriboneVA,PooMM,GreengardP(2002)AproteinkinaseA-dependentmolecularswitchinsynapsinsregulatesneuriteoutgrowth.NatureNeurosci5:431-437.

MooreRY,BernsteinM(1989)SynaptogenesisintheratsuprachiasmaticnucleusdemonstratedbyelectronmicroscopyandsynapsinIimmunoreactivity.JNeurosci9:2151-2162.

NayakAS,MooreCI,BrowningMD(1996)CaMkinaseIIphosphorylationofthepresynapticproteinsynapsinispersistentlyincreasedduringexpressionoflong-termpotentiation.ProcNatlAcadSci(USA)93:15451-15456.

StoneLM,BrowningMD,FingerTE(1994)Differentialdistributionofthesynapsinsintheratolfactorybulb.JNeurosci14:301-309.

Note:Dr.MichaelBrowningandDr.AndrewCzernik,co-authorsofthecitedpapersarethePresidentandChiefScientificOfficerofPhosphoSolutionsandtwoofitsfounders.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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